Inactivation of Gi proteins induces an antidepressant-like effect in the mouse forced-swimming test
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چکیده
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Evaluation of antidepressant effect of ethanolic extract of Rosa damascena using forced swimming test
Objective: Rosa damascena mill L (R. damascena) is a medicinal plant mostly known in the world for its perfume. It also has beneficial effects on stress, tension and depression. In this experiment antidepressant effect of ethanolic extract of R. damascena by forced swimming test (FST) was evaluated. Material and Methods: Animals received ethanolic extract (15, 60 and 90 mg/kg, i.p), imipramine...
متن کاملEffect of potassium channel modulators in mouse forced swimming test.
1. The effect of intracerebroventricular (i.c.v.) administration of different potassium channel blockers (tetraethylammonium, apamin, charybdotoxin, gliquidone), potassium channel openers (pinacidil, minoxidil, cromakalim) and aODN to mKv1.1 on immobility time was evaluated in the mouse forced swimming test, an animal model of depression. 2. Tetraethylammonium (TEA; 5 microg per mouse i.c.v.), ...
متن کاملSynthesis and Antidepressant Activity of N-Substituted Imidazole-5-Carboxamides in Forced Swimming Test Model
Moclobemide is a selective and reversible monoamine oxidase-A inhibitor, which is used as an antidepressant. Three moclobemide analogues were synthesized by replacing moclobemide phenyl ring with substituted imidazoles. So, N-[(4-morpholinyl) ethyl)]-1-benzyl-2-(alkylthio)-1H-imidazole-5-carboxamides (7a-c) were synthesized and studied for the antidepressant activity using forced swimming test ...
متن کاملSynthesis and Antidepressant Activity of N-Substituted Imidazole-5-Carboxamides in Forced Swimming Test Model
Moclobemide is a selective and reversible monoamine oxidase-A inhibitor, which is used as an antidepressant. Three moclobemide analogues were synthesized by replacing moclobemide phenyl ring with substituted imidazoles. So, N-[(4-morpholinyl) ethyl)]-1-benzyl-2-(alkylthio)-1H-imidazole-5-carboxamides (7a-c) were synthesized and studied for the antidepressant activity using forced swimming test ...
متن کاملAntidepressant-Like Effects of Lycii Radicis Cortex and Betaine in the Forced Swimming Test in Rats
The purpose of the present study was to examine the effect of Lycii Radicis Cortex (LRC) and betaine (BT) on immobility and neurochemical change in the forced swimming test (FST) in the rat. LRC, BT or fluoxentine was administered intraperitoneally to Sprague-Dawley rats three times (1, 5 and 23.5 h) before the FST. To investigate antidepressant-like effect, serotonin (5-HT) and norepinephrine ...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2002
ISSN: 0028-3908
DOI: 10.1016/s0028-3908(02)00089-8